Tranexamic Acid(1197-18-8)
Hōʻike huahana
● Tranexamic Acid(1197-18-8)
● CAS No.:·1197-18-8
● EINECS Helu: 356.2222
● MF: C8H15NO2
● Pūʻolo: 25Kg / Drum
● ʻO Tranexamic acid (TXA) he lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana a i ʻole ka pale ʻana i ke kahe nui ʻana o ke koko mai ka ʻeha nui, ke kahe ʻana o ka hānau ʻana, ka ʻoki ʻana, ka wehe ʻana i nā niho, nā koko ihu, a me ka haʻi haʻahaʻa.[2][3]Hoʻohana ʻia ia no ka angioedema hoʻoilina.[2][4]Lawe ʻia ma ka waha a i ʻole ma ke ʻano o ka vein.
Mechanism o ka hana
ʻO ka waika Tranexamic kahi analog synthetic o ka amino acid lysine.Hoʻohana ia ma ke ʻano he antifibrinolytic ma o ka hoʻopaʻa ʻana i ʻehā a ʻelima mau wahi lysine receptor ma plasminogen.Hoʻemi kēia i ka hoʻololi ʻana o ka plasminogen i plasmin, e pale ana i ka hoʻohaʻahaʻa ʻana i ka fibrin a me ka mālama ʻana i ke ʻano o ke ʻano matrix o fibrin. ʻO ka waika Tranexamic ma kahi o ʻewalu mau manawa o ka hana antifibrinolytic o kahi analogue kahiko, ε-aminocaproic acid. ka hana o ka plasmin me ka ikaika nawaliwali (IC50 = 87 mM), a hiki ke ālai i ka pae hana o ka urokinase plasminogen activator (uPA) me ka kiko'ī kiʻekiʻe (Ki = 2 mM), kekahi o nā mea kiʻekiʻe loa ma waena o nā serine proteases.
Nā hana o ka waikawa Tranexamic
Hoʻohana pinepine ʻia ka waika Tranexamic ma hope o ka ʻeha nui.[13]Hoʻohana ʻia ʻo Tranexamic acid e pale a mālama i ke kahe o ke koko ma nā ʻano ʻano like ʻole, e like me nā kaʻina hana niho, ke koko menstrual kaumaha, a me nā ʻokiʻoki me ka nui o ke kahe koko.
| Nā mea ho'āʻo | Koina Pharmacopeial | Ka hopena hoao | |
| NA HUA | ʻAno: Keʻokeʻo a ʻaneʻane keʻokeʻo paha, ka pauka crystalline | ʻO ka pauka kristal keʻokeʻo | |
| Hiki ke hoʻoheheʻe ʻia: Hiki ke hoʻoheheʻe ʻia i ka wai a me ka waikawa acetic glacial, hiki ʻole ke hoʻoheheʻe ʻia i ka acetone a me ka ethanol (96%) | Holo | ||
| IKE | Infrared Absorption Spectrophotometry: IR spectrum i kulike me Tranexamic acid CRS | Holo | |
| HOAO | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Nā mea pili (HPLC2.2.29) | haumia A≤ 0.1 % | ʻAʻole ʻike ʻia | |
| haumia B≤ 0.2% | 0.03% | ||
| Nā mea haumiaC ʻO nā mea haumia ʻole≤ 0.10% Nā mea haumia D Nā mea haumia ʻē aʻe | 0.002% 0.001% ʻAʻole ʻike ʻia | ||
| Huina o na haumia i hoakaka ole ia≤ 0.2% | 0.003% | ||
| Hōʻike ʻia nā Halides ma ke ʻano he Klorida | ≤140ppm | <140ppm | |
| Nalo ma ka maloo | ≤0.5% | 0.026% | |
| Lehu Sulphated | ≤0.1% | 0.027% | |
| HANA | Pono i loko (Ma muli o ka maloʻo) 99.0% 〜101.0% | 100.1% | |
