Gliclazide(21187-98-4)
Papa inoa Huahana
ʻO Gliclazide kahi lāʻau antidiabetic waha sulfonylurea.He keʻokeʻo keʻokeʻo a i ʻole ka pauka crystalline, ʻaʻole ʻono a ʻono ʻole.
ʻO Gliclazide kahi lāʻau hypoglycemic oral sulfonylurea oral me ka hana ikaika.Ua like kona ʻano me ka toluenosulfonylurea, ʻo ia hoʻi, ke koho nei ia i nā pancreatic β-cells e hoʻoikaika i ka huna ʻana o ka insulin a hoʻonui i ka hoʻokuʻu ʻana o ka insulin ma hope o ka ʻai ʻana i ka glucose, ʻaʻole hiki ke hoʻomaikaʻi wale i ka metabolism o nā mea maʻi maʻi maʻi, akā hoʻomaikaʻi a hoʻopaneʻe paha i ka hiki ʻana mai. ʻo nā pilikia vascular diabetic.
Hoʻohana nui ʻia ʻo Gliclazide no ka maʻi maʻi a me ke ʻano maʻamau II me ka hoʻomaka ʻana o nā pākeke kahi i kūpono ʻole ai ka ʻai ʻana a me ka hoʻomaʻamaʻa hoʻomaʻamaʻa ʻole a me ka ʻole o ka ketosis, a hoʻomaikaʻi hoʻi i nā ʻeha fundus a me ka metabolic a me ka vascular dysfunctions i nā maʻi maʻi maʻi.
Palapala noi
Hoʻohana ʻia ʻo Gliclazide no ka mālama ʻana i ka hyperglycemia i ka gliclazide-responsive diabetes mellitus o ka paʻa, maʻalahi, non-ketosis prone, type 2 diabetes.Hoʻohana ʻia ia i ka wā ʻaʻole hiki ke hoʻomalu ʻia ka maʻi diabetes e ka hoʻokele pono ʻana i ka meaʻai a me ka hoʻoikaika kino a i ʻole ke kūpono ʻole ka lāʻau insulin.
| Hoao | Nā kikoʻī | Nā hopena o ka nānā ʻana |
| Ka nana aku | Pauda keʻokeʻo a aneane keʻokeʻo. | Pauda keʻokeʻo |
| Ka hoʻoheheʻe | ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai;hiki ke hoʻoheheʻe ʻia i ka methylene chloride;hiki ke hoʻoheheʻe ʻia i ka acetone;hiki ke hoʻoheheʻe iki ʻia i ka ethanol (96 pākēneka). | Kū i nā koi |
| ʻIkepili | Kūlike ka spectrum absorption infrared me ka mea i loaʻa me ka Gliclazide CRS. | Kū i nā koi |
| haumia B (Na HPLC) | ≤2ppm | 0.5ppm |
| Nā metala kaumaha | ≤10ppm | <10ppm |
| Nā mea pili (Na HPLC) | haumia F ≤0.1% | ʻAʻole ʻike ʻia |
| ʻO kēlā me kēia haumia i hōʻike ʻole ʻia ≤0.10% | 0.04% | |
| ʻO ka huina o nā haumia ʻē aʻe ma mua o F ≤0.2% | 0.11% | |
| Pohō ma ka maloʻo | ≤0.25% | 0.11% |
| Lehu hū | ≤0.1% | 0.03% |
| Nā mea hoʻoheheʻe koena (Na GC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N,N-Dimethylformamide NMT 880 ppm | ʻAʻole ʻike ʻia | |
| Hoʻāʻo | 99.0-101.0%, ma ke kumu maloʻo. | 100.0% |
| Ka hopena | Kūlike nā hopena hōʻike me EP8. | |
