Ceftifur Hydrochloride(103980-44-5)
Hōʻike huahana
ʻO Ceftiofur kahi lāʻau antibiotic o ke ʻano cephalosporin (ke kolu o ka hanauna), i laikini ʻia no ka hoʻohana ʻana i ka lāʻau lapaʻau holoholona.Ua wehewehe mua ʻia i ka makahiki 1987.
He kū'ē ia i ka enzyme pale antibiotic beta-lactamase, a he hana kūʻē i nā hua bacteria Gram-positive a me Gram-negative.Ua hōʻike ʻia nā maʻi E. coli kūʻē i ka ceftiofur.
ʻO Ceftiofur Hydrochloride ka ʻano paʻakai hydrochloride o ceftiofur, he semisynthetic, beta-lactamase-stable, broad-spectrum, ʻekolu-hanauna cephalosporin me ka hana antibacterial.Hoʻopaʻa ʻo Ceftiofur a hoʻopau i nā protein paʻa penicillin-binding (PBPs) i loaʻa ma ka membrane o loko o ka paia cell bacteria.ʻO nā PBPs nā enzymes i komo i nā pae hope o ka hui ʻana i ka paia cell bacteria a me ka hoʻololi hou ʻana i ka paia cell i ka wā ulu a me ka māhele.ʻO ka hoʻopau ʻole ʻana o nā PBP e hoʻopilikia i ka hoʻopili ʻana o nā kaulahao peptidoglycan e pono ai no ka ikaika a me ka paʻakikī o ka pā cell cell bacteria.ʻO kēia ka hopena i ka nāwaliwali o ka paia cell bacteria a hoʻoulu i ka cell lysis.
| NA MEA | OLELO HOOLAHA | HANA | |
| Ka nana aku | Keʻokeʻo i ka pauka Crystalline keʻokeʻo | Hoʻohālike | |
| ʻIkepili | ʻO ka manawa paʻa o ka piko nui ma ka chromatogram i loaʻa me ka hopena hoʻāʻo e pili ana i ka piko nui o ka chromatogram i loaʻa me ka hoʻonā kuhikuhi. | Hoʻohālike | |
| Pane o Chloride | Hoʻohālike | ||
| ʻO ke ʻano o ka hoʻonā | Maopopo | ʻAʻole ikaika ma mua o No.1 Turbidity Standard | <1 |
| kala kala | ʻAʻole ʻoi aku ka pōʻeleʻele ma mua o ka hopena maʻamau Y9 | <8 | |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka N, N- Dimethylacetamide, liʻiliʻi hiki ke hoʻoheheʻe ʻia i 5% o ka sodium bicarbonate a me ka methanol. | Hoʻohālike | |
| PH | 2.0~3.0 | 2.2 | |
| Waiwai | 1.5%~4.0% | 1.6% | |
| ʻO ka huli ʻana o ka optical kikoʻī | -115°~-127° | -117° | |
| Metala kaumaha | NMT 0.0020% | Hoʻohālike | |
| Ke koena o ke ahi | NMT 0.20% | 0.15% | |
| Nā mea pili | ʻO ka haumia nui loa | NMT 0.20% | 0.09 |
| Huina haumia | NMT 1.50% | 0.38 | |
| Nā mea hoʻoheheʻe koena | Ethyl Acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Hoʻāʻo | ʻO Ceftifur Hydrochloride | NLT 98.0% | 100.4% |
| Klorida | 6.0%~6.5% | 6.2% | |
| Endotoxin maʻi bacteria | Ma lalo o 0.20EU/mg | Hoʻohālike | |
| ʻO ka maʻemaʻe | Kūlike i ka hoʻāʻo | Hoʻohālike | |
| Nui ʻāpana | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| OLELO HOOLAHA | HUI KA HO'O I KA HO'O | ||
